The 17-alpha-alkyl group in the structure of the drug allows you to bypass the liver without breaking down, but this makes Anadrol toxic to the liver. Studies were conducted with a duration of 30 weeks, where the subjects used Oxymetholone at a dose of 50 mg per day. As a result, various side effects have been identified, including on the liver Oxymetholone.
In the 2003 Schroeder study, subjects received a dose of 50 or 100 mg / day, while only one of the subjects had a significant increase in ALT (alanine aminotransferase) over 12 weeks of continuous use. But, as it turned out later, this was due to the intake of alcohol immediately before donating blood. On reanalysis, no increase in ALT was found. In all other subjects, ALT and ASAT increased slightly, but invariably remained within the normal range. Thus, the toxic effect on the liver is largely exaggerated. The safest dosage of the drug is 100 mg per day (or less).
It should also be noted that oxymetholone is not converted to estrogens, however, quite often it can cause fluid accumulation in the body, gynecomastia, increase blood pressure, and some others. It is assumed that Anadrol itself can bind and activate estrogen receptors, therefore, on the course, the level of estradiol should be monitored, and based on this, aromatase inhibitors should be used, or it is more preferable to take blockers of the above receptors.
It should be noted that oxymetholone does not have progestogenic activity, and there is not a single study that would clearly indicate its presence. The drug itself is a derivative of dihydrotestosterone.
In some cases (when using large doses), the drug can cause diarrhea, impair appetite, and cause mild nausea. Oxymetholone suppresses the production of its own testosterone to a lesser extent than most steroids.